皇牌專利益生菌

---

美國FDA認證菌株

日本森永乳業獨家菌種

眾多功效 超過100篇文獻支持

臨床效果證實

改善過敏/增強免疫力/加強排便

緩解兒童上呼吸道疾病症狀、增加大腸益菌

減少花粉症病發症狀等

-改善上呼吸道疾病-

1.BB536 可緩解學齡前兒童的上呼吸道疾病並調節腸道微生物群.

Bifidobacterium longum BB536 alleviated upper respiratory illnesses and modulated gut microbiota profiles in Malaysian pre-school children

Beneficial microbes 9.1 (2018): 61-70

-改善過敏-

1.BB536的免疫刺激 DNA 序列可抑制 IgE 產生，抑制過敏反應.

An immunostimulatory DNA sequence froma probiotic strain of Bifidobacterium longum inhibits IgE production in vitro.
FEMS Immunol. Med. Microbiol. 46 (2006) 461–469

2.BB536的免疫刺激 DNA 序列可改善 Th1/Th2 平衡，降低過敏反應.

Oral Administration of an Immunostimulatory DNA sequence from Bifidobacterium longum Improves Th1/Th2 Balance in a Murine Model.
Biosci. Biotechnol. Biochem. 70 (8), 2013-2017, 2006

3.BB536的去氧核糖多醣體可調整Th-2，降低過敏反應.

Immunostimulatory oligodeoxynucleotide from Bifidobacterium longum suppresses Th-2 immune responses in a murine model.
Clinical and Experimental Immunology. 2006, 145: 130–138

4.BB536的細胞壁促進Th1 能達到抑製Th2 過敏反應作用.

In vitro Th1 Cytokine-Independent Th2 Suppressive Effects of Bifidobacteria.
Microl. Immunol., 2007, 51(7), 649-660

5.BB536對 T 細胞-抗原呈現細胞交互作用誘導的 Th2 吸引趨化因子產生的抑製作用.

Suppressive effects of Bifidobacterium longum on the production of Th2-attracting chemokines induced with T cell-antigen-presenting cell interactions.
FEMS Immunol Med Microbiol 55 (2009) 324–334

-改善花粉症-

1.BB536在花粉季節緩解花粉症臨床症狀和調節血漿細胞激素水平的作用.

Effect of Probiotic Bifidobacterium longum BBS36 in relieving clinical symptoms and modulating plasma cytokine levels of Japanese cedar pollinosis during the pollen season. A randomized double-blind, placebo controlled trial.
J Investig Allergol Clin Immunol, 2006; Vol. 16(2): 86-93

2.能調整血清過敏數值.

Changes in Plasma TARC Levels during Japanese Cedar Pollen Season and Relationships with Symptom Development.
Microl. Int. Arch Allergy Immunol., 2007, 144:123-127

3.治療花粉症，雙盲安慰劑對照試驗，調整過敏反應系統，有效降低花粉症的徵狀.

Probiotics in the treatment of Japanese cedar pollinosis: a double-blind placebo-controlled trial.
Clinical and Experimental Allergy, 36, 1425–1435

4.BB536治療花粉過敏症狀的臨床療效在環境暴露裝置中進行評估，有效降低過敏症狀.

Clinical Efficacy of Probiotic Bifidobacterium longum for the Treatment of Symptoms of Japanese Cedar Pollen Allergy in Subjects Evaluated in an Environmental Exposure Unit.
Allergology Internatinal. 2007;56:67-75

5.花粉症患者微生物群的波動以及益生菌攝取量的影響，腸內菌的比例跟過敏有關.

Fluctuation of Fecal Microbiota in Individuals With Japanese Cedar Pollinosis During the Pollen Season and Influence of Probiotic Intake.
J Investig Allergol Clin Immunol 2007; Vol. 17(2): 92-100

6.花粉症患者腸內壞菌較多，BB536可降低壞菌數.

Distribution of Different Species of the Bacteroides fragilis Group in Individuals with Japanese Cedar Pollinosis.
Applied and environmental Microbiology, 2008, 6814

-預防流感-

1.BB536對老年人流感感染、流感疫苗抗體滴度和細胞介導免疫的影響，發現BB536可以有效預防流感.

Effects of Bifidobacterium longum BB536 Administration on Influenza Infection, Influenza Vaccine Antibody Titer, and Cell-Mediated Immunity in the Elderly.
Biosci. Biotechnol. Biochem., 74(5), 939-975, 2010

2.口服BB536可改善流感病毒感染.

Oral Administration of Bifidobacterium longum Ameliorates Influenza Virus Infection in Mice.
Biol. Pharm. Bull. 34(8) 1352—1355 (2011)

-提升嬰兒腸道健康、改善過敏-

1.實驗結果顯示益生菌組較安慰劑組，可以觀察到比較多好菌與較少的壞菌.

Effect of a Milk Formula Containing Probiotics on the Fecal Microbiota of Asian Infants at Risk of Atopic Dieseases.
Pediatric Research Vol.62 No.06, 2007

2.實驗結果顯示BB536會影響腸中菌叢生態.

The impact of perinatal probiotic intervention on gut microbiota: Double-blind placebo-controlled trials in Finland and Germany.
Anaerobe. 2011 Sep 29.

3.高風險亞洲嬰兒出生後前 6 個月補充益生菌—對 1 歲時濕疹和異位性過敏的影響，結果顯示可以改善一些過敏指數.

Probiotic supplementation in the first 6 months of life in at risk Asian infants – effects on eczema and atopic sensitization at the age of 1 year.
Clinical & Experimental Allergy, 39, 571–578

臨床效果證實

改善異位性皮膚炎或其他過敏疾病

改善兒童氣喘發作

針對調節腸道菌群平衡，舒緩敏感體質

GMNL-133可以調節T細胞，抑制Th2細胞的免疫反應，達到減緩過敏

適應對象：異位性皮膚炎/蕁麻疹/濕疹/氣喘/乾癬/過敏性結膜炎/食物過敏者/季節性過敏

台灣 專利號 I398259

中國 專利號 CN 102399718 A

德、英、法 專利號 EP 2581461

美國 專利號 US8753624

1.患有異位性皮膚炎或其他過敏症狀在接觸乳桿菌後表現出臨床改善.

Wang and Wang (2015). Children with atopic dermatitis show clinical improvement after Lactobacillus exposure. 

Clinical Experimantal Allergy. 45 (4) pp779-787

2. 補充特定乳桿菌可改善學齡兒童氣喘發作嚴重程度 .

Efficacy of Lactobacillus Administration in School-Age Children with Asthma: A Randomized, Placebo-Controlled Trial.

Nutrients 2018 , 10, 1678